Article
Variation in genes of the epidermal differentiation complex in German atopic dermatitis patients.
International journal of immunogenetics - 1 Aug 2009
Stemmler S, Nothnagel M, Parwez Q, Petrasch-Parwez E, Epplen J T, Hoffjan S
Abstract excerpt
The filaggrin (FLG) gene is one of the most widely replicated susceptibility genes for atopic dermatitis (AD) so far. Yet, FLG mutations cannot fully account for the original linkage peak on chromosome 1q21, a region comprising the so-called epidermal differentiation complex (EDC). Since the EDC contains numerous genes relevant for epidermal differentiation, we sought to evaluate variation in other genes located...
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