Article
[Study on the mitochondrial DNA variation in patients with type 2 diabetes mellitus].
Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics - 1 Apr 2007
Ji Jing-zhang, Lu Jian-xin, Ye Wei, Hu Xin, Wang Da-wang
Abstract excerpt
OBJECTIVE: To explore the relationship between type 2 diabetes mellitus (T2DM) and the mutations in the fragment of mitochondrial DNA (mtDNA) from nucleotides 3153 to 3551, which have shown high frequency of point mutation. METHODS: One hundred and ninety-one normal controls and 222 patients with T2DM were screened by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), T-A cloning...
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