Genetic Determinism of Primary Early-Onset Osteoarthritis.

Abstract excerpt

Osteoarthritis (OA) is the most common joint disease worldwide. A minority of cases correspond to familial presentation characterized by early-onset forms which are genetically heterogeneous. This review brings a new point of view on the molecular basis of OA by focusing on gene mutations causing early-onset OA (EO-OA). Recently, thanks to whole-exome sequencing, a gain-of-function mutation in the TNFRSF11B gene...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Age of Onset
• Share to Cartilage
• Share to Collagen