Article
Clinical and Molecular Spectrum of Nonsyndromic Early-Onset Osteoarthritis.
Arthritis & rheumatology (Hoboken, N.J.) - 1 Oct 2020
Ruault Valentin, Yauy Kevin, Fabre Aurélie, Fradin Mélanie, Van-Gils Julien, Angelini Chloé, Baujat Geneviève, Blanchet Patricia, Cuinat Silvestre, Isidor Bertrand, Jorgensen Christian, Lacombe Didier, Moutton Sébastien, Odent Sylvie, Sanchez Elodie, Sigaudy Sabine, Touitou Isabelle, Willems Marjolaine, Apparailly Florence, Geneviève David, Barat-Houari Mouna
Abstract excerpt
OBJECTIVE: Osteoarthritis (OA) is the most common joint disease worldwide. The etiology of OA is varied, ranging from multifactorial to environmental to monogenic. In a condition called early-onset OA, OA occurs at an earlier age than is typical in the general population. To our knowledge, there have been no large-scale genetic studies of individuals with early-onset OA. The present study was undertaken to...
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