Article
Functional importance of polymerization and localization of calsequestrin in C. elegans.
Journal of cell science - 1 May 2007
Cho Jeong Hoon, Ko Kyung Min, Singaruvelu Gunasekaran, Lee Wonhae, Kang Gil Bu, Rho Seong-Hwan, Park Byung-Jae, Yu Jae-Ran, Kagawa Hiroaki, Eom Soo Hyun, Kim Do Han, Ahnn Joohong
Abstract excerpt
Dual roles of calsequestrin (CSQ-1) being the Ca2+ donor and Ca2+ acceptor make it an excellent Ca2+-buffering protein within the sarcoplasmic reticulum (SR). We have isolated and characterized a calsequestrin (csq-1)-null mutant in Caenorhabditis elegans. To our surprise, this mutant csq-1(jh109) showed no gross defects in muscle development or function but, however, is highly sensitive to perturbation of Ca2+...
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