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Article

RhoB plays an essential role in CXCR2 sorting decisions.

Journal of cell science - 1 May 2007

Neel Nicole F, Lapierre Lynne A, Goldenring James R, Richmond Ann

Abstract excerpt

The CXCR2 chemokine receptor is a G-protein-coupled receptor that undergoes clathrin-mediated endocytosis upon ligand binding. The trafficking of CXCR2 is crucial for cells to maintain a proper chemotactic response. The mechanisms that regulate the recycling/degradation sorting decision are unknown. In this study, we used dominant-negative (T19N) and GTPase-deficient activated (Q63L) RhoB mutants, as well as RhoB...

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Source

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Identifiers

PMID: 17405813
DOI: 10.1242/jcs.03437
PMCID: PMC2766565

Genes

CXCR2
CXCL8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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