Article
PTEN hamartoma tumor syndromes.
European journal of human genetics : EJHG - 1 Nov 2008
Blumenthal Gideon M, Dennis Phillip A
Abstract excerpt
The PTEN hamartoma tumor syndromes (PHTS) are a collection of rare clinical syndromes characterized by germline mutations of the tumor suppressor PTEN. These syndromes are driven by cellular overgrowth, leading to benign hamartomas in virtually any organ. Cowden syndrome (CS), the prototypic PHTS syndrome, is associated with increased susceptibility to breast, thyroid, and endometrial cancer. PTEN is located on...
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