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Loricrin: Past, Present, and Future

25 Mar 2020

Abstract excerpt

The terminal differentiation of the epidermis is a complex physiological process. During the past few decades, medical genetics has shown that defects in the stratum corneum (SC) permeability barrier cause a myriad of pathological conditions, ranging from common dry skin to lethal ichthyoses. Contrarily, molecular phylogenetics has revealed that amniotes have acquired a specialized form of cytoprotection...

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PMID: 32218335
DOI: 10.3390/ijms21072271

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