Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Aloxe3 knockout mice reveal a function of epidermal lipoxygenase-3 as hepoxilin synthase and its pivotal role in barrier formation.

The Journal of investigative dermatology - 1 Jan 2013

Krieg Peter, Rosenberger Sabine, de Juanes Silvia, Latzko Susanne, Hou Jin, Dick Angela, Kloz Ulrich, van der Hoeven Frank, Hausser Ingrid, Esposito Irene, Rauh Manfred, Schneider Holm

Abstract excerpt

Loss-of-function mutations in the lipoxygenase (LOX) genes ALOX12B and ALOXE3 are the second most common cause of autosomal recessive congenital ichthyosis. The encoded proteins, 12R-LOX and epidermal LOX-3 (eLOX-3), act in sequence to convert fatty acid substrates via R-hydroperoxides to specific epoxyalcohol derivatives and have been proposed to operate in the same metabolic pathway during epidermal barrier...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Arachidonate 12-Lipoxygenase
Share to Ceramides

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epidermis

Share to Fatty Acids, Nonesterified

Share to Ichthyosis

Share to Intramolecular Oxidoreductases

Share to Lipids

Share to Lipoxygenase

Source

Identifiers

PMID: 22832496
DOI: 10.1038/jid.2012.250

Genes

LOX
ALOXE3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Aloxe3 knockout mice reveal a function of epidermal lipoxygenase-3 as hepoxilin synthase and its pivotal role in barrier formation.PMID 22832496Read ↗

12R-lipoxygenase deficiency disrupts epidermal barrier function.Semantic proximity Read ↗

The lipoxygenase gene ALOXE3 implicated in skin differentiation encodes a hydroperoxide isomerase.Semantic proximity Read ↗

Development of an ichthyosiform phenotype in Alox12b-deficient mouse skin transplants.Semantic proximity Read ↗

Hepoxilin A3 (HXA3) synthase deficiency is causative of a novel ichthyosis form.Semantic proximity Read ↗

The role of lipoxygenases in epidermis.Semantic proximity Read ↗

Acylceramide is a key player in skin barrier function: insight into the molecular mechanisms of skin barrier formation and ichthyosis pathogenesisSemantic proximity Read ↗

Molecular analysis of 250 patients with autosomal recessive congenital ichthyosis: evidence for mutation hotspots in ALOXE3 and allelic heterogeneity in ALOX12B.Semantic proximity Read ↗

Mutation spectrum and functional analysis of epidermis-type lipoxygenases in patients with autosomal recessive congenital ichthyosis.Semantic proximity Read ↗

Loss of ceramide synthase 3 causes lethal skin barrier disruptionSemantic proximity Read ↗

Impaired epidermal ceramide synthesis causes autosomal recessive congenital ichthyosis and reveals the importance of ceramide acyl chain length.Semantic proximity Read ↗

A mouse mutation in the 12R-lipoxygenase, Alox12b, disrupts formation of the epidermal permeability barrier.Semantic proximity Read ↗

Meta-Analysis of Mutations in ALOX12B or ALOXE3 Identified in a Large Cohort of 224 Patients.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.