Article
Development of an ichthyosiform phenotype in Alox12b-deficient mouse skin transplants.
The Journal of investigative dermatology - 1 Jun 2009
de Juanes Silvia, Epp Nikolas, Latzko Susanne, Neumann Mareen, Fürstenberger Gerhard, Hausser Ingrid, Stark Hans-Jürgen, Krieg Peter
Abstract excerpt
12R-lipoxygenase (12R-LOX) represents a key enzyme of a recently identified eicosanoid pathway in the skin that plays an essential role in the establishment and/or maintenance of the epidermal barrier function. Genetic studies show that loss-of-function mutations in ALOX12B, encoding 12R-LOX, and in ALOXE3, encoding another closely related LOX involved in this pathway, are the second most common cause for...
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