Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mgat5 and Pten interact to regulate cell growth and polarity.

Glycobiology - 1 Jul 2007

Cheung Pam, Dennis James W

Abstract excerpt

Phosphatase and tensin homolog (Pten) phosphatase opposes intracellular phosphoinositide 3-kinase (PI3K)/Akt signaling and is a potent tumor suppressor, while Golgi beta1,6 N-acetylglucosaminyltransferase V (Mgat5) is positively associated with cancer progression and metastasis. beta1,6GlcNAc-branched N-glycans on receptor glycoproteins promote their surface residency and sensitizes cells to growth factor...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Adhesion
Share to Epistasis, Genetic
Share to Extracellular Signal-Regulated MAP Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fibroblasts

Share to Models, Biological

Share to N-Acetylglucosaminyltransferases

Share to PTEN Phosphohydrolase

Share to Surface Properties

Source

Identifiers

PMID: 17400585
DOI: 10.1093/glycob/cwm037

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mgat5 and Pten interact to regulate cell growth and polarity.PMID 17400585Read ↗

Posttranslational regulation of phosphatase and tensin homolog (PTEN) and its functional impact on cancer behaviorsSemantic proximity Read ↗

Tumor suppressor PTEN: modulator of cell signaling, growth, migration and apoptosisSemantic proximity Read ↗

PTEN gene and integrin signaling in cancer.Semantic proximity Read ↗

Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN.Semantic proximity Read ↗

Hyperphosphorylated PTEN exerts oncogenic properties.Semantic proximity Read ↗

Involvement of TGFβ-induced phosphorylation of the PTEN C-terminus on TGFβ-induced acquisition of malignant phenotypes in lung cancer cells.Semantic proximity Read ↗

The adaptor protein AMOT promotes the proliferation of mammary epithelial cells via the prolonged activation of the extracellular signal-regulated kinases.Semantic proximity Read ↗

Integrin α5 Suppresses the Phosphorylation of Epidermal Growth Factor Receptor and Its Cellular Signaling of Cell Proliferation via N-Glycosylation.Semantic proximity Read ↗

Loss of Stat5a delays mammary cancer progression in a mouse model.Semantic proximity Read ↗

Posttranslational regulation of membrane type 1-matrix metalloproteinase (MT1-MMP) in mouse PTEN null prostate cancer cells: Enhanced surface expression and differential O-glycosylation of MT1-MMP.Semantic proximity Read ↗

α-Mannosidase 2C1 attenuates PTEN function in prostate cancer cells.Semantic proximity Read ↗

Nuclear PTEN-mediated growth suppression is independent of Akt down-regulation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.