Article
XRCC2 and XRCC3 gene polymorphism and risk of pancreatic cancer.
The American journal of gastroenterology - 1 Feb 2008
Jiao Li, Hassan Manal M, Bondy Melissa L, Wolff Robert A, Evans Douglas B, Abbruzzese James L, Li Donghui
Abstract excerpt
OBJECTIVES: XRCC2 and XRCC3 are key components of the homologous recombination (HR) machinery that repairs DNA double-strand breaks. We hypothesized that the altered HR repair capacity conferred by single nucleotide polymorphisms (SNPs) would modify individual susceptibility to sporadic pancreatic cancer. METHODS: In a hospital-based case-control study, genomic DNA and exposure information was obtained from 468...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
