Article
A corresponding tyrosine residue in the C2/factor B type A domain is a hot spot in the decay acceleration of the complement C3 convertases.
The Journal of biological chemistry - 26 Dec 2003
Kuttner-Kondo Lisa A, Dybvig Megan P, Mitchell Lynne M, Muqim Nasima, Atkinson John P, Medof M Edward, Hourcade Dennis E
Abstract excerpt
The cleavage of C3 by the C3 convertases (C3bBb and C4b2a) determines whether complement activation proceeds. Dissociation (decay acceleration) of these central enzymes by the regulators decay-accelerating factor (DAF), complement receptor 1 (CR1), factor H, and C4-binding protein (C4BP) controls their function. In a previous investigation, we obtained evidence implicating the alpha4/5 region of the type A domain...
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