Conservation in decay accelerating factor (DAF) structure among primates.

doi:10.1016/s0145-305x(00)00026-4

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Article

Conservation in decay accelerating factor (DAF) structure among primates.

Developmental and comparative immunology - 1 Dec 2000

Kuttner-Kondo L, Subramanian V B, Atkinson J P, Yu J, Medof M E

Abstract excerpt

The decay accelerating factor (DAF, CD55) protects self cells from activation of autologous complement on their surfaces. It functions to disable the C3 convertases, the central amplification enzymes of the cascade. Its active site(s) are contained within four approximately 60 amino acid long units, termed complement control protein repeats (CCPs), which are suspended above the cell surface on a 68 amino acid...

Topics

Alternative Splicing
Amino Acid Sequence
Animals
CD55 Antigens
Cell Line
Complement C3
Erythrocebus patas
Erythrocytes
Gene Deletion
Genetic Variation
Gorilla gorilla
Leukocytes, Mononuclear
Macaca mulatta
Male
Molecular Sequence Data
Pan troglodytes
Papio
Primates

Source

Open in PubMed

Identifiers

PMID: 10906393
DOI: 10.1016/s0145-305x(00)00026-4

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