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Article

Complement regulation at the molecular level: The structure of decay-accelerating factor

20 Jan 2004

Abstract excerpt

The human complement regulator CD55 is a key molecule protecting self-cells from complement-mediated lysis. X-ray diffraction and analytical ultracentrifugation data reveal a rod-like arrangement of four short consensus repeat (SCR) domains in both the crystal and solution. The stalk linking the four SCR domains to the glycosylphosphatidylinositol anchor is extended by the addition of 11 highly charged O-glycans...

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PMID: 14734808
DOI: 10.1073/pnas.0307200101

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