Article
Bax mutation and overexpression inversely correlate with immature phenotype and prognosis of childhood germ cell tumors.
Oncology reports - 1 May 2007
Addeo Raffaele, Crisci Stefania, D'Angelo Velia, Vincenzi Bruno, Casale Fiorina, Pettinato Guido, Donofrio Vittoria, Boldrini Renata, Alaggio Rita, Collini Paola, Bertorelle Roberta, Di Tullio Maria Teresa, Caraglia Michele, Terenziani Monica, Lo Curto Margherita, Indolfi Paolo
Abstract excerpt
Primary childhood germ cell tumors (GCTs) represent a rare and heterogeneous group of tumors that varies in histologic differentiation, age of presentation and clinical outcome. In malignant neoplasms, apoptosis is a prognostic marker and a predictive factor of response to therapy. Therefore, the study of the expression and mutation of molecules involved in the regulation of apoptosis could be useful in order to...
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