Article
Molecular genetic analysis of BAX and cyclin D1 genes in patients with malignant glioma.
Neurological research - 1 Apr 2007
Abdullah Jafri Malin, Ahmad Farizan, Ahmad Ku Asmarina Ku, Ghazali Mazira Mohamad, Jaafar Hasnan, Ideris Aini, Ali Abdul Manaf, Omar Abdul Rahman, Yusoff Khatijah, Lila Mohd Azmi Mohd, Othman Fauziah
Abstract excerpt
INTRODUCTION AND OBJECTIVES: Brain tumorigenesis is a complex process involving multiple genetic alterations. Cyclin D1 and BAX genes are two of the most important regulators in controlling the normal proliferation and apoptosis of cells, respectively. In this study, we analysed the possibilities of involvement of cyclin D1 and BAX genes in the gliomagenesis. METHODS AND RESULTS: In determining gene alterations...
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