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Article

Mechanistic Role of <i>I</i> <sub>f</sub> Revealed by Induction of Ventricular Automaticity by Somatic Gene Transfer of Gating-Engineered Pacemaker (HCN) Channels

28 Mar 2007

Abstract excerpt

BACKGROUND: Although I(f), encoded by the hyperpolarization-activated cyclic-nucleotide-modulated (HCN) channel gene family, is known to be functionally important in pacing, its mechanistic action is largely inferential and indeed somewhat controversial. To dissect in detail the role of I(f), we investigated the functional consequences of overexpressing in adult guinea pig left ventricular cardiomyocytes (LVCMs)...

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PMID: 17389267
DOI: 10.1161/circulationaha.106.659391

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