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Article

Cutting, Amplifying, and Aligning Microtubules with Severing Enzymes.

Trends in cell biology - 1 Jan 2021

Kuo Yin-Wei, Howard Jonathon

Abstract excerpt

Microtubule-severing enzymes - katanin, spastin, fidgetin - are related AAA-ATPases that cut microtubules into shorter filaments. These proteins, also called severases, are involved in a wide range of cellular processes including cell division, neuronal development, and tissue morphogenesis. Paradoxically, severases can amplify the microtubule cytoskeleton and not just destroy it. Recent work on spastin and...

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Identifiers

PMID: 33183955
DOI: 10.1016/j.tcb.2020.10.004
PMCID: PMC7749064

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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