Article
Validation of the association between the gene encoding proteasome subunit alpha type 6 and myocardial infarction in a Japanese population.
Circulation journal : official journal of the Japanese Circulation Society - 1 Apr 2007
Takashima Naoyuki, Shioji Keisuke, Kokubo Yoshihiro, Okayama Akira, Goto Yoichi, Nonogi Hiroshi, Iwai Naoharu
Abstract excerpt
BACKGROUND: Recently, a large case-control study (2,851 cases and 2,592 controls) reported that a functional single nuclear polymorphism (SNP) in the proteasome subunit alpha type 6 gene (PSMA6) conferred a risk of myocardial infarction (MI) in a Japanese population. The SNP (exon 1, -8C/G) is located in the 5' untranslated region of exon 1, and the risk-conferring allele G appears to enhance the transcription of...
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