Article
Cbl-dependent ubiquitination is required for progression of EGF receptors into clathrin-coated pits.
Molecular biology of the cell - 1 Aug 2004
Stang Espen, Blystad Frøydis D, Kazazic Maja, Bertelsen Vibeke, Brodahl Tonje, Raiborg Camilla, Stenmark Harald, Madshus Inger Helene
Abstract excerpt
Ligand binding causes the EGF receptor (EGFR) to become ubiquitinated by Cbl upon association with the adaptor protein Grb2. We have investigated the role of ubiquitin and Grb2 in ligand-induced endocytosis of the EGFR. Incubation of cells with EGF on ice caused translocation of Grb2 and Cbl from the cytosol to the rim of coated pits. Grb2 with point mutations in both SH3 domains inhibited recruitment of the EGFR...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.