Article
Acetylator phenotype, aminobiphenyl-hemoglobin adduct levels, and bladder cancer risk in white, black, and Asian men in Los Angeles, California.
Journal of the National Cancer Institute - 4 May 1994
Yu M C, Skipper P L, Taghizadeh K, Tannenbaum S R, Chan K K, Henderson B E, Ross R K
Abstract excerpt
BACKGROUND: There is a large body of epidemiologic and experimental data that have identified a number of arylamines as human bladder carcinogens. Metabolic activation is required to biotransform these arylamines into their carcinogenic forms, and N-hydroxylation, which is catalyzed by the hepatic cytochrome P4501A2 isoenzyme, is generally viewed as the first critical step. On the other hand, the N-acetylation...
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