Multiple high-throughput analyses monitor the response of E. coli to perturbations.

doi:10.1126/science.1132067

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Article

Multiple high-throughput analyses monitor the response of E. coli to perturbations.

Science (New York, N.Y.) - 27 Apr 2007

Ishii Nobuyoshi, Nakahigashi Kenji, Baba Tomoya, Robert Martin, Soga Tomoyoshi, Kanai Akio, Hirasawa Takashi, Naba Miki, Hirai Kenta, Hoque Aminul, Ho Pei Yee, Kakazu Yuji, Sugawara Kaori, Igarashi Saori, Harada Satoshi, Masuda Takeshi, Sugiyama Naoyuki, Togashi Takashi, Hasegawa Miki, Takai Yuki, Yugi Katsuyuki, Arakawa Kazuharu, Iwata Nayuta, Toya Yoshihiro, Nakayama Yoichi, Nishioka Takaaki, Shimizu Kazuyuki, Mori Hirotada, Tomita Masaru

Abstract excerpt

Analysis of cellular components at multiple levels of biological information can provide valuable functional insights. We performed multiple high-throughput measurements to study the response of Escherichia coli cells to genetic and environmental perturbations. Analysis of metabolic enzyme gene disruptants revealed unexpectedly small changes in messenger RNA and proteins for most disruptants. Overall, metabolite...

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PMID: 17379776
DOI: 10.1126/science.1132067

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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