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Identification of a new intrinsically timed developmental checkpoint that reprograms key hematopoietic stem cell properties

22 Mar 2007

Abstract excerpt

Hematopoietic stem cells (HSCs) execute self-renewal divisions throughout fetal and adult life, although some of their properties do alter. Here we analyzed the magnitude and timing of changes in the self-renewal properties and differentiated cell outputs of transplanted HSCs obtained from different sources during development. We also assessed the expression of several "stem cell" genes in corresponding...

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Share to Epigenetics and DNA Methylation
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PMID: 17379664
DOI: 10.1073/pnas.0700460104

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