Article
A developmental role for catecholamines in Drosophila behavior.
Pharmacology, biochemistry, and behavior - 1 Aug 2005
Pendleton Robert G, Rasheed Aseel, Paluru Prasuna, Joyner Jeannettee, Jerome Natalie, Meyers Robert D, Hillman Ralph
Abstract excerpt
Tyrosine hydroxylase (TH), the enzyme which catalyzes the conversion of tyrosine to L-DOPA and is the rate limiting step in catecholamine biosynthesis, is genetically expressed during development in Drosophila. Null mutant alleles of the single copy gene which codes for this enzyme are developmentally lethal as is a conditional TH mutant at its restrictive temperature. In adult flies, inhibition of TH by...
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