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Article

The Drosophila tyramine beta-hydroxylase gene is required for ethanol tolerance.

Scientific reports - 11 Apr 2026

Ruppert Manuela, Hampel Stefanie, Claßen Gerbera, Fuchs Claire, Kell Thomas, Paluri Sravya, Scholz Henrike

Abstract excerpt

Tyramine beta-hydroxylase (Tbh) is required for octopamine synthesis. To better understand the function of Tbh in neurotransmitter synthesis in Drosophila melanogaster, we analyzed the molecular genetic organization of the Tbh gene and found that it encodes multiple transcripts. The transcripts differed in their 5′ untranslated region, and the resulting proteins differed in size. We identified new Tbh alleles and...

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Identifiers

PMID: 41965381
DOI: 10.1038/s41598-026-45082-3
PMCID: PMC13076892

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