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Article

Deficits in brain serotonin synthesis in a genetic mouse model of phenylketonuria.

Neuroreport - 20 Dec 2002

Pascucci Tiziana, Ventura Rossella, Puglisi-Allegra Stefano, Cabib Simona

Abstract excerpt

Although hyperphenylalaninemia causes neurological disturbances and mental retardation, the neuropathological effects of phenylalanine excess are still poorly understood. Brain serotonin depletion may play a major role in such disturbances and is a possible target for feasible pharmacotherapies. In the present study, we investigated hyperphenylalaninemia-related brain serotonin depletion using a genetic mouse...

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Identifiers

PMID: 12499868
DOI: 10.1097/00001756-200212200-00036

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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