Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Polymorphism of dihydropyrimidine dehydrogenase (DPYD) Cys29Arg and risk of six malignancies in Japanese.

Nagoya journal of medical science - 1 Jun 2005

Tanaka Daisuke, Hishida Asahi, Matsuo Keitaro, Iwata Hiroji, Shinoda Masayuki, Yamamura Yoshitaka, Kato Tomoyuki, Hatooka Shunzo, Mitsudomi Tetsuya, Kagami Yoshitoyo, Ogura Michinori, Tajima Kazuo, Suyama Motokazu, Naito Mariko, Yamamoto Kazuhito, Tamakoshi Akiko, Hamajima Nobuyuki

Abstract excerpt

Dihydropyrimidine dehydrogenase (DPD) is the enzyme catalyzing the first step of pyrimidine metabolism. To date, genetic polymorphisms of pyrimidine-synthesizing enzymes have been reported to be associated with the risk of malignant lymphoma or colon cancer. Accordingly, there may be associations between dihydropyrimidine dehydrogenase (DPYD) polymorphism and the risk of malignancies. We conducted a prevalent...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Arginine
Share to Chi-Square Distribution

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cysteine

Share to Dihydrouracil Dehydrogenase (NADP)

Share to Models, Biological

Share to Neoplasms

Share to Odds Ratio

Source

Identifiers

PMID: 17375478

Genes

DPYD

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Polymorphism of dihydropyrimidine dehydrogenase (DPYD) Cys29Arg and risk of six malignancies in Japanese.PMID 17375478Read ↗

Functional Characterization of 21 Allelic Variants of Dihydropyrimidine Dehydrogenase Identified in 1070 Japanese Individuals.Semantic proximity Read ↗

Genetic variations and haplotype structures of the DPYD gene encoding dihydropyrimidine dehydrogenase in Japanese and their ethnic differences.Semantic proximity Read ↗

Germline Mutation of Dihydropyrimidine Dehydrogenese Gene among a Japanese Population in Relation to Toxicity to 5‐FluorouracilSemantic proximity Read ↗

Dihydropyrimidine dehydrogenase (DPYD) gene c.1627A>G A/G and G/G genotypes are risk factors for lymph node metastasis and distant metastasis of colorectal cancer.Semantic proximity Read ↗

DPYD genotype and haplotype analysis and colorectal cancer susceptibility in a case-control study from Slovakia.Semantic proximity Read ↗

Dihydropyrimidine dehydrogenase pharmacogenetics in the Taiwanese population.Semantic proximity Read ↗

Screening of dihydropyrimidine dehydrogenase genetic variants by direct sequencing in different ethnic groups.Semantic proximity Read ↗

Polymorphisms of dihydropyrimidine dehydrogenase gene and clinical outcomes of gastric cancer patients treated with fluorouracil-based adjuvant chemotherapy in Chinese population.Semantic proximity Read ↗

[Dihydropyrimidine dehydrogenase activity and its genetic aberrations].Semantic proximity Read ↗

Novel single nucleotide polymorphisms of the dihydropyrimidinase gene (DPYS) in Japanese individuals.Semantic proximity Read ↗

Methylenetetrahydrofolate reductase gene (MTHFR) polymorphisms and reduced risk of malignant lymphoma.Semantic proximity Read ↗

MGMT Leu84Phe polymorphism contributes to cancer susceptibility: evidence from 44 case-control studies.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.