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Article

DPYD genotype and haplotype analysis and colorectal cancer susceptibility in a case-control study from Slovakia.

General physiology and biophysics - 1 Dec 2017

Matáková Tatiana, Halašová Erika, Škovierová Henrieta, Dzian Anton, Dobrota Dušan, Škereňová Mária

Abstract excerpt

Dihydropyrimidine dehydrogenase (DPD) acts as the first-step enzyme catabolizing pyrimidines in vivo. DPYD gene mutations interfere with the breakdown of uracil and thymine. Genetic variations of DPYD can cause an enzyme deficiency state, which results in severe toxicity or other adverse side effects such as DNA damage or RNA damage caused by imbalance of the nucleotide pool. Our case-control study investigates...

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Source

Identifiers

PMID: 29372689
DOI: 10.4149/gpb_2017046

Genes

DPYD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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