Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Immunological differences between susceptible and resistant sheep during the preclinical phase of scrapie infection.

The Journal of general virology - 1 Apr 2007

Eaton S L, Rocchi M, González L, Hamilton S, Finlayson J, Sales J, Jeffrey M, Steele P J, Dagleish M P, Rodger S M, Reid H W, Chianini F

Abstract excerpt

In order to investigate the relationship between the immune response to scrapie infection and genetic susceptibility to the disease in sheep, immune cell subsets and prion protein (PrP) expression were determined in susceptible and resistant Suffolk sheep in the preclinical phase of infection. At 6 months of age, 12 ARQ/ARQ (susceptible) and nine ARR/ARR (resistant) scrapie-free Suffolk lambs were challenged...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Flow Cytometry
Share to Immunity, Innate

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Leukocytes, Mononuclear

Share to Lymph Nodes

Share to Lymphocyte Subsets

Share to Prions

Share to Sheep Diseases

Source

Identifiers

PMID: 17374786
DOI: 10.1099/vir.0.82197-0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Immunological differences between susceptible and resistant sheep during the preclinical phase of scrapie infection.PMID 17374786Read ↗

Lack of prion accumulation in lymphoid tissues of PRNP ARQ/ARR sheep intracranially inoculated with the agent of scrapie.Semantic proximity Read ↗

Role of lymph-borne cells in the early stages of scrapie agent dissemination from the skin.Semantic proximity Read ↗

Biology of PrPsc accumulation in two natural scrapie-infected sheep flocks.Semantic proximity Read ↗

Early accumulation of PrP(Sc) in gut-associated lymphoid and nervous tissues of susceptible sheep from a Romanov flock with natural scrapie.Semantic proximity Read ↗

Healthy sheep that differ in scrapie associated PRNP genotypes exhibit significant differences of expression pattern associated with immune response and cell-to-cell signalling in retropharyngeal lymph nodes.Semantic proximity Read ↗

PrP(Sc) deposition in nervous tissues without lymphoid tissue involvement is frequently found in ARQ/ARQ Sarda breed sheep preclinically affected with natural scrapie.Semantic proximity Read ↗

Expression of selected genes isolated from whole blood, liver and obex in lambs with experimental classical scrapie and healthy controls, showing a systemic innate immune response at the clinical end-stage.Semantic proximity Read ↗

Diagnosis and PrP genotype target of scrapie in clinically healthy sheep of Massese breed in the framework of a scrapie eradication programme.Semantic proximity Read ↗

Occurrence and distribution of infection-specific PrP in tissues of clinical scrapie cases and cull sheep from scrapie-affected farms in Shetland.Semantic proximity Read ↗

Fewer PrPc myeloid-based cells in sheep with the prion-resistant genotype.Semantic proximity Read ↗

High prevalence of scrapie in a dairy goat herd: tissue distribution of disease-associated PrP and effect of PRNP genotype and age.Semantic proximity Read ↗

Cell-associated variants of disease-specific prion protein immunolabelling are found in different sources of sheep transmissible spongiform encephalopathy.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.