Article
Fewer PrPc myeloid-based cells in sheep with the prion-resistant genotype.
Neuroreport - 6 Feb 2006
Herrmann Lynn M, Baszler Timothy V, O'Rourke Katherine I, Suarez Carlos E, Bakko Marlene, Alverson Janet, Knowles Donald P
Abstract excerpt
Numerous sheep with the prion gene (PRNP) that encodes for 171QQ develop scrapie, a neurodegenerative prion disease of sheep. Relatively few cases of scrapie-affected sheep with PRNP genetics that encode for 171RR, however, have been found. Using flow cytometric analysis, statistically fewer PrPc...
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