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Article

Structural Basis for Enhancement of Carbapenemase Activity in the OXA-51 Family of Class D β-Lactamases

4 Jun 2015

Abstract excerpt

Class D β-lactamases of Acinetobacter baumannii are enzymes of the utmost clinical importance, producing resistance to last resort carbapenem antibiotics. Although the OXA-51-like enzymes constitute the largest family of class D β-lactamases, they are poorly studied and their importance in conferring carbapenem resistance is controversial. We present the detailed microbiological, kinetic, and structural...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 26042471
DOI: 10.1021/acschembio.5b00090

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