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Article

Role of Arginine 214 in the Substrate Specificity of OXA-48.

Antimicrobial agents and chemotherapy - 21 Apr 2020

Oueslati Saoussen, Retailleau Pascal, Marchini Ludovic, Berthault Camille, Dortet Laurent, Bonnin Rémy A, Iorga Bogdan I, Naas Thierry

Abstract excerpt

Increasing numbers of variants of the carbapenem-hydrolyzing class D β-lactamase OXA-48 are identified in Enterobacterales worldwide. Among them, OXA-181 and OXA-232 are of particular interest, as they differ from each other by a single amino acid substitution at position 214 (R in OXA-181 and S in OXA-232) that results in reduced carbapenem-hydrolyzing activity for OXA-232. To investigate the role of amino acid...

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Identifiers

PMID: 32071047
DOI: 10.1128/AAC.02329-19
PMCID: PMC7179614

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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