Article
Epistatic relationship between the cancer susceptibility genes CHEK2 and p27.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Mar 2007
Cybulski Cezary, Gliniewicz Bartłomiej, Sikorski Andrzej, Kładny Józef, Huzarski Tomasz, Gronwald Jacek, Byrski Tomasz, Debniak Tadeusz, Gorski Bohdan, Jakubowska Anna, Wokolorczyk Dominika, Narod Steven A, Lubiñski Jan
Abstract excerpt
We studied the effects of p27 and CHEK2 variants on prostate and colon cancer risk in a case-control study. Modest effects on prostate cancer risk were observed for both CHEK2 missense and truncating variants. However, the excess cancer risk was restricted to the subgroup of men who were homozygous for the VV genotype in codon 109 of the p27 gene. Among men with the VV p27 genotype, the odds ratios associated...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.