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Article

Relapse in children with acute lymphoblastic leukemia involving selection of a preexisting drug-resistant subclone

19 Mar 2007

Abstract excerpt

Relapse following remission induction chemotherapy remains a barrier to survival in approximately 20% of children suffering from acute lymphoblastic leukemia (ALL). To investigate the mechanism of relapse, 27 matched diagnosis and relapse ALL samples were analyzed for clonal populations using polymerase chain reaction (PCR)-based detection of multiple antigen receptor gene rearrangements. These clonal markers...

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Identifiers

PMID: 17371950
DOI: 10.1182/blood-2007-01-067785

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