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Article

Biologic pathways associated with relapse in childhood acute lymphoblastic leukemia: a Children's Oncology Group study

29 Mar 2006

Abstract excerpt

Outcome for children with childhood acute lymphoblastic leukemia (ALL) who relapse is poor. To gain insight into the mechanisms of relapse, we analyzed gene-expression profiles in 35 matched diagnosis/relapse pairs as well as 60 uniformly treated children at relapse using the Affymetrix platform. Matched-pair analyses revealed significant differences in the expression of genes involved in cell-cycle regulation,...

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PMID: 16822902
DOI: 10.1182/blood-2006-02-002824

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