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Article

A new Aspergillus fumigatus resistance mechanism conferring in vitro cross-resistance to azole antifungals involves a combination of cyp51A alterations.

Antimicrobial agents and chemotherapy - 1 Jun 2007

Mellado E, Garcia-Effron G, Alcázar-Fuoli L, Melchers W J G, Verweij P E, Cuenca-Estrella M, Rodríguez-Tudela J L

Abstract excerpt

Fourteen Aspergillus fumigatus clinical isolates that exhibited a pattern of reduced susceptibility to triazole drugs were analyzed. The sequences of the cyp51A gene from all isolates showed the presence of a point mutation at t364a, which led to the substitution of leucine 98 for histidine (L98H), together with the presence of two copies of a 34-bp sequence in tandem in the promoter of the cyp51A gene....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Cytochrome P-450 Enzyme System

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Source

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Identifiers

PMID: 17371828
DOI: 10.1128/AAC.01092-06
PMCID: PMC1891382

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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