Article
Azole resistance in Aspergillus fumigatus: a side-effect of environmental fungicide use?
The Lancet. Infectious diseases - 1 Dec 2009
Verweij Paul E, Snelders Eveline, Kema Gert H J, Mellado Emilia, Melchers Willem J G
Abstract excerpt
Invasive aspergillosis due to multi-azole-resistant Aspergillus fumigatus has emerged in the Netherlands since 1999, with 6.0-12.8% of patients harbouring resistant isolates. The presence of a single resistance mechanism (denoted by TR/L98H), which consists of a substitution at codon 98 of cyp51A...
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