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Article

Triazole fungicides can induce cross-resistance to medical triazoles in Aspergillus fumigatus.

PloS one - 1 Jan 2012

Snelders Eveline, Camps Simone M T, Karawajczyk Anna, Schaftenaar Gijs, Kema Gert H J, van der Lee Henrich A, Klaassen Corné H, Melchers Willem J G, Verweij Paul E

Abstract excerpt

BACKGROUND: Azoles play an important role in the management of Aspergillus diseases. Azole resistance is an emerging global problem in Aspergillus fumigatus, and may develop through patient therapy. In addition, an environmental route of resistance development has been suggested through exposure to 14α-demethylase inhibitors (DMIs). The main resistance mechanism associated with this putative fungicide-driven...

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Identifiers

PMID: 22396740
DOI: 10.1371/journal.pone.0031801
PMCID: PMC3291550

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