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Article

Recombinant human hemoglobins designed for gene therapy of sickle cell disease.

11 Oct 1994

Abstract excerpt

Two human hemoglobins designed to inhibit the polymerization of sickle hemoglobin (Hb S; alpha 2 beta S2) have been produced. Mutations that disrupt the ability of Hb S to form polymers were introduced into the normal human beta-globin gene by site-specific mutagenesis. These mutations affect the axial and lateral contacts in the sickle fiber. The recombinant hemoglobin designated anti-sickling hemoglobin 1 (Hb...

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Identifiers

PMID: 7937904
DOI: 10.1073/pnas.91.21.9852

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