Expression, purification, and characterization of human hemoglobins Gower-1 (ζ2ε2), Gower-2 (α2ε2), and Portland-2 (ζ2β2) assembled in complex transgenic–knockout mice

Abstract excerpt

Embryonic zeta- and epsilon-globin subunits assemble with each other and with adult alpha- and beta-globin subunits into hemoglobin heterotetramers in both primitive and definitive erythrocytes. The properties of these hemoglobins-Hbs Gower-1 (zeta(2)epsilon(2)), Gower-2 (alpha(2)epsilon(2)), and Portland-2 (zeta(2)beta(2))-have been incompletely described as they are difficult to obtain in quantity from either...

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