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Article

Phosphatidylinositol4-phosphate 5-kinase prevents the decrease in the HERG potassium current induced by Gq protein-coupled receptor stimulation.

Journal of pharmacological sciences - 1 Jan 2015

Kubo Taeko, Ding Wei-Guang, Toyoda Futoshi, Fujii Yusuke, Omatsu-Kanbe Mariko, Matsuura Hiroshi

Abstract excerpt

The human ether-a-go-go-related gene (HERG) potassium current (IHERG) has been shown to decrease in amplitude following stimulation with Gq protein-coupled receptors (GqRs), such as α1-adrenergic and M1-muscarinic receptors (α1R and M1R, respectively), at least partly via the reduction of membrane phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2). The present study was designed to investigate the modulation of...

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Identifiers

PMID: 25704028
DOI: 10.1016/j.jphs.2014.11.013

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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