Article
STAT-1 decoy oligonucleotide improves microcirculation and reduces acute rejection in allogeneic rat small bowel transplants.
Gene therapy - 1 Jun 2007
Stojanovic T, Scheele L, Wagner A H, Middel P, Bedke J, Lautenschläger I, Leister I, Panzner S, Hecker M
Abstract excerpt
During acute rejection leukocyte-endothelial cell interaction fuelled by costimulatory molecules such as the CD40/CD154 receptor/ligand dyad disrupts microcirculation of the small bowel. Downregulating endothelial CD40 expression by employing a decoy oligonucleotide (dODN) neutralizing the transcription factor signal transducer and activator of transcription-1 (STAT-1) may protect the graft. Therefore allogenic...
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