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Unraveling the Crucial Roles of FoxP3+ Regulatory T Cells in Vascularized Composite Allograft Tolerance Induction and Maintenance.

Transplantation - 1 Jun 2021

Anggelia Madonna Rica, Cheng Hui-Yun, Chuang Wen-Yu, Hsieh Yun-Huan, Wang Aline Yen Ling, Lin Chih-Hung, Wei Fu-Chan, Brandacher Gerald, Lin Cheng-Hung

Abstract excerpt

BACKGROUND: The role of regulatory T cells (Treg) in tolerance induction of vascularized composite allotransplantation (VCA) remains unclear. This study was designed to examine characteristics of Treg after VCA and their capacity to rescue allografts from rejection. METHODS: Osteomyocutaneous allografts were transplanted from Balb/c to C57BL/6 mice. All mice received costimulatory blockade and a short course of...

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PMID: 33141809
DOI: 10.1097/TP.0000000000003509

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