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Article

G protein beta3 polymorphism and triptan response in cluster headache.

Clinical pharmacology and therapeutics - 1 Oct 2007

Schürks M, Kurth T, Stude P, Rimmbach C, de Jesus J, Jonjic M, Diener H-C, Rosskopf D

Abstract excerpt

Only about 70% of migraine and cluster headache (CH) patients report significant treatment responses to triptans, which are agonists at 5-HT(1B/D) receptors belonging to the family of G protein-coupled receptors. We analyzed whether a common polymorphism in the gene for the G protein beta3 subunit (GNB3 C825T) modulates responder rates to triptans among a cohort of 231 unrelated Caucasian CH patients. A total of...

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Source

Identifiers

PMID: 17361120
DOI: 10.1038/sj.clpt.6100159

Genes

GNB3

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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