Article
Analysis of HCRTR2, GNB3, and ADH4 Gene Polymorphisms in a Southeastern European Caucasian Cluster Headache Population.
Journal of molecular neuroscience : MN - 1 Mar 2020
Papasavva Maria, Katsarou Martha-Spyridoula, Vikelis Michail, Mitropoulou Euthymia, Dermitzakis Emmanouil V, Papakonstantinou Stylianos, Arvaniti Chryssa, Mitsikostas Dimos-Dimitrios, Gozes Illana, Tsatsakis Aristides M, Drakoulis Nikolaos
Abstract excerpt
Studies point to an increased hereditary risk of cluster headache. HCRTR2 gene rs2653349 and ADH4 gene rs1800759 polymorphisms have been associated with cluster headache susceptibility. Also, GNB3 rs5443 polymorphism, associated with increased signal transduction via GPCRs, seems to influence triptan treatment response. DNA from 114 cluster headache patients and 570 non-related controls, representing a general...
Read the complete abstract on PubMed