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Article

5-hydroxytryptamine1B receptor and triptan response in migraine, lack of association with common polymorphisms.

European journal of pharmacology - 2 Feb 2008

Velati Daniela, Viana Michele, Cresta Stefania, Mantegazza Paola, Testa Lucia, Bettucci Diego, Rinaldi Maurizio, Sances Grazia, Tassorelli Cristina, Nappi Giuseppe, Canonico Pier Luigi, Martignoni Emilia, Genazzani Armando A

Abstract excerpt

Triptans mediate vasoconstriction of meningeal vessels via stimulation of vascular 5-hydroxytryptamine (5-HT)(1B) receptors. These drugs are recommended for acute treatment in patients with moderate-to-severe migraine attacks and in those patients with mild-to-moderate headache that are not controlled adequately by other agents. Yet, approximately 25% of all migraine users and 40% of all attacks do not respond to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 18035351
DOI: 10.1016/j.ejphar.2007.10.058

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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