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Article

The pRb/E2F cell-cycle pathway mediates cell death in Parkinson's disease

21 Feb 2007

Abstract excerpt

The mechanisms leading to degeneration of dopaminergic neurons (DNs) in the substantia nigra of patients with Parkinson's disease (PD) are not completely understood. Here, we show, in the postmortem human tissue, that these neurons aberrantly express mitosis-associated proteins, including the E2F-1 transcription factor, and appear to duplicate their nuclear DNA. We further demonstrate that the dopaminergic...

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Share to Neurogenesis and neuroplasticity mechanisms
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Identifiers

PMID: 17360686
DOI: 10.1073/pnas.0611671104

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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