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Article

Photoreceptor proliferation and dysregulation of cell cycle genes in early onset inherited retinal degenerations.

BMC genomics - 11 Mar 2016

Gardiner Kristin L, Downs Louise, Berta-Antalics Agnes I, Santana Evelyn, Aguirre Gustavo D, Genini Sem

Abstract excerpt

BACKGROUND: Mitotic terminally differentiated photoreceptors (PRs) are observed in early retinal degeneration (erd), an inherited canine retinal disease driven by mutations in the NDR kinase STK38L (NDR2). RESULTS: We demonstrate that a similar proliferative response, but of lower magnitude, occurs in two other early onset disease models, X-linked progressive retinal atrophy 2 (xlpra2) and rod cone dysplasia 1...

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Source

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Identifiers

PMID: 26969498
DOI: 10.1186/s12864-016-2477-9
PMCID: PMC4788844

Genes

CCNA1
CCNE1
CDK2
LATS1

Provenance

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