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Article

The Nestin progenitor lineage is the compartment of origin for pancreatic intraepithelial neoplasia.

Proceedings of the National Academy of Sciences of the United States of America - 13 Mar 2007

Carrière Catherine, Seeley Elliott S, Goetze Tobias, Longnecker Daniel S, Korc Murray

Abstract excerpt

To determine the cell compartment in which initial oncogenic mutations occur in pancreatic ductal adenocarcinoma (PDAC), we generated a mouse model in which endogenous expression of mutated Kras (Kras(G12D)) was initially directed to a population of pancreatic exocrine progenitors characterized by the expression of Nestin. Targeting of oncogenic Kras to such a restricted cell compartment was sufficient for the...

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Identifiers

PMID: 17360542
DOI: 10.1073/pnas.0701117104
PMCID: PMC1810329

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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